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Ages Eligible for Study: 3 months and older
Genders Eligible for Study: Both

Study Population

All orders for IVIG received by the UHN Blood Transfusion Service will be reviewed by the study coordinator to identify potential study participants

Eligibility Criteria

Inclusion Criteria: 

  • cumulative dose within a 28-day period equal or greater to 2 g/kg body weight, adjusted for lean body mass

  • non-O blood group

  • willing to provide blood samples immediately prior to, immediately after the completion of, and 5-10 days after the course of IVIG therapy

  • Able to provide informed consent, either themselves or through a surrogate decision-maker

Exclusion Criteria:

  • evidence of active bleeding or hemolytic anemia at time of enrolment (patients with chronic, stable anemia will be eligible following review by the principle investigator)

  • concurrently prescribed transfusion therapy